Somehow, doing research on rural mail delivery in Colorado, I stumbled across this photo of downtown Minneapolis, 1905, and ended up wandering around for hours in the turn-of-the-century Gateway District. It's worth going to the site where I found it to view the wonderfully detailed original.
The corner in the foreground is South Fourth Street and Second Avenue. The first of three buildings facing Second is a mixed use three-story with tenant laundry on the roof, housing a seller of Gluek's Beer, a pool room and possibly a grocery (another photo I've seen advertised a laundry at the second awning). The Northern Hotel is in the middle and the famed Metropolitan Building dominates the shot.
In the large-format version, you can see how trolleys, horse-drawn wagons and bikes are the main conveyances, though there may be one motor car parked on Fourth. In the lower left, an awning marks a hay store — or maybe that's just the name of the proprietor.
The last building along far end of Fourth is the Wyman Building, which still stands, and I can pick out a few other existing buildings in the Warehouse District, including the Jackson Building and the Colonial Warehouse (home of the city's horse drawn trolley system and site of a recent PARKing Day encampment), with its tall, pale smokestack visible abover the Metropolitan Building.
In Twin Cities Then and Now, Larry Millett wrote about this area:
Like other old sections of American downtowns, the Gateway was a place of magnificent detail, as cluttered and inviting as a Victorian parlor. The buildings visible here [a closer-in, lower view of the same main block], including the Metropolitan bristle with all manner of parapets, cornices, finials, chimneys, fire escapes, towers, domes, and other assorted protrusions [...] It is not a beautiful scene, but this little piece of Minneapolis looks wonderefully appealing, a place where a stroller would never lack entertainment for the eyes.